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Background The degree of post-injury inflammation of the damaged area of a spinal cord is the main difference between the natural successful repair in inferior vertebrates and failure in superior vertebrates. The treatment of rats with anti-myelin lymphocytes after experimental spinal cord injury induces their functional recovery. On the other hand, mesenchymal stem cells (MSC)...
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Background This is a preliminary report on successful results obtained during treatment of two patients with chronic spinal cord injury. The therapeutic approach was based on the generation of controlled inflammatory activity at the injury site that induced a microenviron- ment for the subsequent administration of autologous, BM-driven transdifferentiated neural stem cells (NSC).
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Abstract Introduction: It has been previously shown that adult mes- enchymal stem cells (MSCs) differentiate into neural progen- itor cells (NPCs) and that the differentiation process was completed in 24–48 h. In this previous study, MSCs from a bone marrow or fat source were co-incubated with homolo- gous autoaggressive cells (ECs) against nerve tissue, and...
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