By Huang, Young, Skaper, Chene, Moviglia et al. Published in the Journal of Orthopaedic Translation. Volume 20, January 2020, Pages 14-24Read More

The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”.Read More

Abstract Despite the metabolic dysfunctions found in Amyotrophic Lateral Sclerosis (ALS) motoneurons, the uncontrolled Injury/Repair Microglia function seems to be the main responsible for the fast and fatal disease progression.Read More

Uncontrolled activation of the innate immune system promotes the deterioration of neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at the Weizmann Institute of Science (Israel) during the late 1970s and has been demonstrated to be an effective treatment for human autoimmune diseases...Read More

Background The degree of post-injury inflammation of the damaged area of a spinal cord is the main difference between the natural successful repair in inferior vertebrates and failure in superior vertebrates. The treatment of rats with anti-myelin lymphocytes after experimental spinal cord injury induces their functional recovery. On the other hand, mesenchymal stem cells (MSC)...Read More

Background This is a preliminary report on successful results obtained during treatment of two patients with chronic spinal cord injury. The therapeutic approach was based on the generation of controlled inflammatory activity at the injury site that induced a microenviron- ment for the subsequent administration of autologous, BM-driven transdifferentiated neural stem cells (NSC).Read More