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Cell Therapy for Circulatory Insufficiency

With local immunomodulation

Cell Therapy

Stem cells in combination with effector lymphocytes have proven to be great allies in combating varicose veins, vascular insufficiency and other diseases derived from circulatory problems in the legs, such as ulcers or arteritis obliterans.

Trials have been developed for the treatment of circulatory insufficiency problems in the lower extremities caused by the variants mentioned above. Cell therapy has proven to be effective because it attacks the root of the problem: poor blood supply due to damage to the veins or arteries of the legs.

Clinical tests have been based on the application of vascular progenitor cells with local immunomodulation. These cells are obtained in the laboratory from mesenchymal stem cells whose predifferentiation is driven and regulated by the patient’s own effector lymphocytes.

When implanted in the patient, two basic effects are generated: damaged blood vessels are repaired and new ducts are generated through which blood can circulate. This is known as revascularization.


After stem cell application, the first sign of recovery is a progressive decrease in pain and signs of improved tissue perfusion.

We present several photographs of patients treated with stem cells in combination with effector lymphocytes. The cases are diverse. In the first, the mesenchymal stem cells have been used to generate new vessels, which are completely visible only 6 months after the patient received the cell implant.

In the second case, an existing vessel is noticeably repaired after 12 months of receiving the cells.

Reparación - Antes

Finally, we present a case where the appearance of a cloud of blood vessels is recorded at only 3 months, which is a first sign that the revascularization process has been initiated.

The following case was of a patient who presented ulcer in his lower extremities. After receiving the cell therapy these were the results.

Úlcera Antes
  • Improve the conditions for the arrival of blood to the lower limbs: increasing the diameter of sclerosed arterial vessels and favoring the formation of new blood vessels.
  • Generate an inflammatory environment that facilitates repair around the lesion.
Úlcera después
  • Increase the turgor and elasticity of the vein walls to optimize blood return and thus avoid edema and accumulation of toxins in the lower limbs.
  • To provide cells that can replace the missing tissue.

Causes of circulatory insufficiency

Various affections of the arteries and veins can generate circulatory insufficiency, which is more evident in the lower extremities.

Varicose veins and venous insufficiency

La insuficiencia venosa ocurre como resultado de un aumento prolongado de la presión que ejerce la sangre sobre las paredes venosas. Esto degenera el tejido elástico y provoca el mal funcionamiento de las válvulas de las venas, por lo que la sangre se acumula y se generan venas anormalmente dilatadas y tortuosas (várices), que son incapaces de contraerse para empujar el flujo sanguíneo.

An estimated 10-20% of the general population eventually develops varicose veins in the lower legs. This condition is much more common in overweight people over 50 years of age and in women.

The disease, as mentioned above, can present various stages of complication, depending on the level of irrigation compromise. The more severe the patient’s condition, the greater the necrotic effect of the insufficiency of nutrients carried by the blood, leading to inflamed veins and even chronic ulcers.


Chronic ulcers in the lower limbs have a high negative impact on the quality of life of those who suffer from them, usually associated with chronic pain and functional limitation that affects walking and resistance to standing. Varicose veins and poorly controlled diabetes are two of the most frequent causes. This terrible ailment is present in up to 5% of the population over 65 years of age.

Arteritis Obliterante

Varicose veins are problems that occur in the veins. But there is another variant of circulatory problem that affects the arteries. This is arteritis obliterans or Friedlander’s disease. In the case of arteritis, the problem arises due to inflammation of the cells that line the blood vessel, causing partial or complete obstruction of the artery and thus decreasing the irrigation of legs and feet.

Arteritis causes fatigue, pain or a feeling of heaviness in the legs during walking, but when at rest the symptoms improve. As the disease worsens, the feeling of relief disappears and people can walk shorter distances. In the most severe cases, the pain persists even at rest, and there are also alterations in the characteristics of the skin, ulcers and, finally, gangrene leading to amputation.

Enfermedad Arterial Periférica

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