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Cell Therapy for Rotator Cuff Injury

With local immunomodulation

Cell therapy

Mesenchymal stem cells have the capacity to pre-differentiate into various tissues, in order to regenerate them. In this particular case, they can be applied pre-differentiated to tendon and bone tissue producing cells, in combination with activated lymphocytes, by direct injection into the joints that make up the rotator cuff in the shoulder.

In the first instance, the cellular material controls the inflammatory process to stop the damage and generate an environment conducive to repair of the compromised tissue.

The repair is accomplished by the transformation of the implanted stem cells into the target tissue: the tendons and bones of the shoulder. A process of disc repair is then activated that repairs the damage to the joint.

Cell therapy is ideal for those who are unable to tolerate surgery for clinical reasons (advanced age, cardiovascular compromise or any other associated risk factor) or those who choose not to undergo surgery.

After the implantation of the cellular material, after the first 10 days the treatment is complemented with a rehabilitation program aimed at the re-education of the muscles involved in the shoulder movement.

Due to the non-surgical characteristics of the treatment, ultrasound-guided cell implantation cannot be applied when the tendon rupture is complete. In these cases it can be used as an adjuvant to the surgical procedure.


Our clinical experience has shown that critical cases of this disease can recover when cell therapy is combined with an intensive kinesiology program. The following is the case of a patient who received two implants and was able to reduce pain and regain mobility.

What is rotator cuff injury?

It is a disease that is generated by the injury of the tendons that make up the shoulder joints.

The overloading of these muscles for prolonged periods, direct trauma or age-related tissue degeneration are the most frequent causes of this condition.

Pain and movement deficits are the consequence of partial or total tears of the tendons involved and muscle involvement.

Levels of rotator cuff injury

According to the level of damage sustained, rotator cuff injuries can be classified in different ways and require a particular level of care.

  • Acute: In a previously healthy tendon or tendinitis, the patient suffers a trauma, either a blow or sudden elevation of the arm, causing tendon rupture. The patient feels pain immediately after the trauma.
  • Chronic: The tendon suffers tendinitis and chronic degeneration of its fibers, which causes it to rupture very slowly without a single trauma. This causes the patient to have no pain for a long time, even with a ruptured tendon. Many people over the age of 50 have rotator cuff injuries and have no symptoms.
  • Acute on chronic: Patient with a chronic tendon rupture who presents trauma to the shoulder, by blow or sudden elevation of the arm, enlarging the initial chronic injury.

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