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Cell Therapy for Skin Rejuvenation

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With local immunomodulation

Cell Therapy

Cell therapy intervention on skin showing signs of aging aims to provide the necessary tools to rebuild the structure of a youthful dermis and thus restore the balance between the production and degradation of collagen and elastic fibers.

For this purpose, mesenchymal cells pre-differentiated to fibroblasts and cells of the immune system (lymphocytes) are injected into the dermal layer, which together facilitate the process of tissue repair and regeneration. The action of these cells allows to increase the amount of collagen in the skin and to balance the production of enzymes that degrade this important substance.

The reconstruction of the tissue is progressive, therefore cells are gradually placed in the affected areas. Depending on the severity of the situation, 3 to 5 applications are programmed with an interval of 4 weeks between each one.

Conservative treatment uses anti-inflammatory medication of varying potency that may include local corticosteroid infiltrations. It can be combined with rehabilitation aimed at strengthening different muscle groups and postural re-education.

At all times, the patient’s own cells are used. Mesenchymal cells are obtained from subcutaneous fat and lymphocytes from the patient’s own peripheral blood. Both cells are cultured and stimulated in the laboratory with antigens derived from skin tissue and vascular tissue, and then implanted back into the skin to be treated.

Findings

The photos below show the changes observed in patients who participated in our clinical trials, who received skin treatment with cells at the level of the eyes, cheekbones, corners of the lips and chin.

Paciente Rostro
Paciente Cuello

Why does skin age?

It is a condition of natural degeneration caused by the loss of cellular material and its regenerative capacity.

The skin has 3 layers: epidermis, dermis and subcutaneous cellular tissue or hypodermis. The aging process involves all layers.

Collagen fibers together with elastic fibers provide the tension, strength and elasticity of the skin. The fibroblasts of the dermal layer are the main producers and degraders of collagen and other components of the dermis.

The aging of the skin is associated with:

  • Reduction in the amount of collagen (because its production decreases and its degradation increases).
  • Structural changes in the arrangement of elastic fibers and increased degradation.
  • Reduction in the size of fibroblasts and decrease in their functions; while the production of the enzyme that degrades collagen increases.

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