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February 16, 2017
Abstract Despite the metabolic dysfunctions found in Amyotrophic Lateral Sclerosis (ALS) motoneurons, the uncontrolled Injury/Repair Microglia function seems to be the main responsible for the fast and fatal disease progression.
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Uncontrolled activation of the innate immune system promotes the deterioration of neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at the Weizmann Institute of Science (Israel) during the late 1970s and has been demonstrated to be an effective treatment for human autoimmune diseases...
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Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved.
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BACKGROUND: Glioblastoma multiforme (GBM), the most aggressive glioma, presents with a rapid evolution and relapse within the first year, which is attributed to the persistence of tumor stem cells (TSC) and the escape of immune surveillance. Mixed leukocyte culture (MLC) cytoimplant has been shown to function as a power- ful intratumor pro-inflammatory cytokine pump. Tumor...
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Background The degree of post-injury inflammation of the damaged area of a spinal cord is the main difference between the natural successful repair in inferior vertebrates and failure in superior vertebrates. The treatment of rats with anti-myelin lymphocytes after experimental spinal cord injury induces their functional recovery. On the other hand, mesenchymal stem cells (MSC)...
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Background This is a preliminary report on successful results obtained during treatment of two patients with chronic spinal cord injury. The therapeutic approach was based on the generation of controlled inflammatory activity at the injury site that induced a microenviron- ment for the subsequent administration of autologous, BM-driven transdifferentiated neural stem cells (NSC).
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Abstract Introduction: It has been previously shown that adult mes- enchymal stem cells (MSCs) differentiate into neural progen- itor cells (NPCs) and that the differentiation process was completed in 24–48 h. In this previous study, MSCs from a bone marrow or fat source were co-incubated with homolo- gous autoaggressive cells (ECs) against nerve tissue, and...
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