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By Huang, Young, Skaper, Chene, Moviglia et al. Published in the Journal of Orthopaedic Translation. Volume 20, January 2020, Pages 14-24
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Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient
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The results presented here suggest that the combination of immune and regenerative cell therapy may play an important therapeutic role in clinical and histological recovery of chronic muscular atrophy.
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The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”.
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Abstract Despite the metabolic dysfunctions found in Amyotrophic Lateral Sclerosis (ALS) motoneurons, the uncontrolled Injury/Repair Microglia function seems to be the main responsible for the fast and fatal disease progression.
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Uncontrolled activation of the innate immune system promotes the deterioration of neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at the Weizmann Institute of Science (Israel) during the late 1970s and has been demonstrated to be an effective treatment for human autoimmune diseases...
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Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved.
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BACKGROUND: Glioblastoma multiforme (GBM), the most aggressive glioma, presents with a rapid evolution and relapse within the first year, which is attributed to the persistence of tumor stem cells (TSC) and the escape of immune surveillance. Mixed leukocyte culture (MLC) cytoimplant has been shown to function as a power- ful intratumor pro-inflammatory cytokine pump. Tumor...
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